Blar i forfatter "Fretland, Åsmund Avdem"

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    • Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial 

      Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Angelsen, Jon-Helge; Fristrup, Claus W.; Grønbech, Jon Erik; Hemmingsson, Oskar; Isaksson, Bengt; Juel, Ingebjørg Soterud; Larsen, Peter Nørgaard; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Rizell, Magnus; Sandström, Per; Sandvik, Oddvar Mathias; Sparrelid, Ernesto; Taflin, Helena; Taskén, Kjetil; Brudvik, Kristoffer Watten; Fretland, Åsmund Avdem; Horn, Arild; Kleive, Dyre; Labori, Knut Jørgen; Lassen, Kristoffer; Røsok, Bård Ingvald; Søreide, Jon Arne; Tholfsen, Tore; Villanger, Olaug; Waage, Anne (Journal article; Tidsskriftartikkel, 2021-09-20)
      Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled ...

    • A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer 

      Høye, Eirik; Fromm, Bastian; Böttger, Paul H.M.; Domanska, Diana; Kristensen, Annette Torgunrud; Lund-Andersen, Christin; Abrahamsen, Torveig Weum; Fretland, Åsmund Avdem; Dagenborg, Vegar Johansen; Lorenz, Susanne; Edwin, Bjørn von Gohren; Hovig, Eivind; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-14)
      Although microRNAs (miRNAs) contribute to all hallmarks of cancer, miRNA dysregulation in metastasis remains poorly understood. The aim of this work was to reliably identify miRNAs associated with metastatic progression of colorectal cancer (CRC) using novel and previously published nextgeneration sequencing (NGS) datasets generated from 268 samples of primary (pCRC) and metastatic CRC (mCRC; ...

    • Evolution of laparoscopic liver surgery: 20-year experience of a Norwegian high-volume referral center 

      Aghayan, Davit; Kazaryan, Airazat; Fretland, Åsmund Avdem; Røsok, Bård Ingvald; Barkhatov, Leonid; Lassen, Kristoffer; Edwin, Bjørn von Gohren (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-25)
      Background - Laparoscopic liver surgery has evolved to become a standard surgical approach in many specialized centers worldwide. In this study we present the evolution of laparoscopic liver surgery at a single high-volume referral center since its introduction in 1998.<p> <p>Methods - Patients who underwent laparoscopic liver resection (LLR) between August 1998 and December 2018 at the Oslo ...

    • Inflammatory response after laparoscopic versus open resection of colorectal liver metastases: Data from the oslo-comet trial 

      Fretland, Åsmund Avdem; Sokolov, Andrey; Postriganova, Nadezda; Kazaryan, Airazat M.; Pischke, Søren Erik; Nilsson, Per; Rognes, Ingrid Nygren; Bjørnbeth, Bjørn Atle; Fagerland, Morten; Mollnes, Tom Eirik; Edwin, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10)
      Laparoscopic and open liver resection have not been compared in randomized trials. The aim of the current study was to compare the inflammatory response after laparoscopic and open resection of colorectal liver metastases (CLM) in a randomized controlled trial. This was a predefined exploratory substudy within the Oslo CoMetstudy. Forty-five patients with CLM were randomized to laparoscopic (n ...

    • Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study 

      Sahakyan, Mushegh; Aghayan, Davit; Edwin, Bjørn von Gohren; Alikhanov, Ruslan; Britskaia, Natalia; Brudvik, Kristoffer Watten; D’Hondt, Mathieu; De Meyere, Celine; Efanov, Mikhail; Fretland, Åsmund Avdem; Hoff, Rune; Ismail, Warsan; Ivanecz, Arpad; Kazaryan, Airazat; Lassen, Kristoffer; Magdalenić, Tomislav; Parmentier, Isabelle; Røsok, Bård Ingvald; Villanger, Olaug; Yaqub, Sheraz (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-14)
      Background: The role of laparoscopy in the treatment of intrahepatic cholangiocarcinoma (ICC) remains unclear. This multicenter study examined the outcomes of laparoscopic liver resection for ICC.<p> <p>Methods: Patients with ICC who had undergone laparoscopic or open liver resection between 2012 and 2019 at four European expert centers were included in the study. Laparoscopic and open approaches ...

    • Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: amulticenter propensity score-matched study 

      Sahakyan, Mushegh; Aghayan, Davit; Edwin, Bjørn von Gohren; Alikhanov, Ruslan; Britskaia, Natalia; Brudvik, Kristoffer Watten; D’Hondt, Mathieu; De Meyere, Celine; Efanov, Mikhail; Fretland, Åsmund Avdem; Hoff, Rune; Ismail, Warsan; Ivanecz, Arpad; Kazaryan, Airazat M.; Lassen, Kristoffer; Magdalenic, Tomislav; Parmentier, Isabelle; Røsok, Bård Ingvald; Villanger, Olaug; Yakub, Sheraz (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-14)
      Background - The role of laparoscopy in the treatment of intrahepatic cholangiocarcinoma (ICC) remains unclear. This multicenter study examined the outcomes of laparoscopic liver resection for ICC.<p> <p>Methods - Patients with ICC who had undergone laparoscopic or open liver resection between 2012 and 2019 at four European expert centers were included in the study. Laparoscopic and open approaches ...

    • Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer 

      Johansen Dagenborg, Vegard; Marshall, Serena Elizabeth; Grzyb, Krzyzstof; Fretland, Åsmund Avdem; Lund-Iversen, Marius; Mælandsmo, Gunhild Mari; Hansen Ree, Anne; Edwin, Bjørn; Yaqub, Sheraz; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Background: The subtype, density and location of tumor infiltrating T-cells are being explored as prognostic and predictive biomarkers in primary colorectal cancer (pCRC) and colorectal liver metastases (CLM). Very limited data exist comparing findings in pCRC and matched CLM.<p> <p>Patients and methods: Fifty-eight patients with available pCRC and matched CLM (57/58 microsatellite stable) were ...

    • Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases 

      Østrup, Olga; Dagenborg, Vegar Johansen; Rødland, Einar Andreas; Skarpeteig, Veronica; Silwal-Pandit, Laxmi; Grzyb, Krzysztof; Berstad, Audun Elnæs; Fretland, Åsmund Avdem; Mælandsmo, Gunhild; Børresen-Dale, Anne-Lise; Ree, Anne Hansen; Edwin, Bjørn; Nygaard, Vigdis; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-18)
      Background: Metastatic colorectal cancer (CRC) is associated with highly variable clinical outcome and response to therapy. The recently identified consensus molecular subtypes (CMS1-4) have prognostic and therapeutic implications in primary CRC, but whether these subtypes are valid for metastatic disease is unclear. We performed multi-level analyses of resectable CRC liver metastases (CLM) to ...

    • T cell receptor repertoire sequencing reveals chemotherapy-driven clonal expansion in colorectal liver metastases 

      Høye, Eirik; Dagenborg, Vegar Johansen; Kristensen, Annette Torgunrud; Lund-Andersen, Christin; Fretland, Åsmund Avdem; Lorenz, Susanne; Edwin, Bjørn von Gohren; Hovig, Eivind; Fromm, Bastian; Inderberg, Else Marit; Greiff, Victor; Ree, Anne Hansen; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)
      Background - Colorectal liver metastasis (CLM) is a leading cause of colorectal cancer mortality, and the response to immune checkpoint inhibition (ICI) in microsatellite-stable CRC has been disappointing. Administration of cytotoxic chemotherapy may cause increased density of tumor-infiltrating T cells, which has been associated with improved response to ICI. This study aimed to quantify and ...